1243259-19-9
Chemical Structure
LM11A-31 dihydrochloride
- CAS No.: 1243259-19-9
- Formula:C12H27Cl2N3O2
- Molecular Weight:316.27
IUPAC Name: (2S,3S)-2-amino-3-methyl-N-(2-morpholinoethyl)pentanamide dihydrochloride
InChIKey: LLIHJRRZJDEKLB-ULEGLUPFSA-N
SMILES: CC[C@H](C)[C@H](N)C(NCCN1CCOCC1)=O.Cl.Cl
Biological Activity: LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression[1][2].
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LM11A-31 dihydrochloride | 99.93% | LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. | ||||||||||||||||||||
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LM11A-31 dihydrochloride (Standard) | ≥98% | LM11A-31 dihydrochloride (Standard) is the analytical standard of LM11A-31 (dihydrochloride) (HY-110155). This product is intended for research and analytical applications. LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. | ||||||||||||||||||||
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References
- [1]. Elshaer SL, et al. Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinalvascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62(8):1488-1500. [Content Brief]
- [2]. Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136. [Content Brief]
