1243266-04-7
1243266-04-7
Chemical Structure
Tovetumab
Synonym(s): MEDI-575
- CAS No.: 1243266-04-7
- Formula:N/A
- Molecular Weight:(145.39 kDa)
IUPAC Name: tert-butyl (2-acetyl-4-fluorophenyl)carbamate
SMILES: [Tovetumab]
Biological Activity: Tovetumab (MEDI-575) is an anti-PDGFRα monoclonal antibody that selectively blocks the PDGFRα signal transduction. Tovetumab can be used in the research of glioblastoma and non-small cell lung cancer (NSCLC)[1][2].
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Tovetumab | 99% | Tovetumab (MEDI-575) is an anti-PDGFRα monoclonal antibody that selectively blocks the PDGFRα signal transduction. Tovetumab can be used in the research of glioblastoma and non-small cell lung cancer (NSCLC). | ||||||||||||||||||||
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References
- [1]. Meina Liang, et al. A Novel Pharmacodynamic Biomarker and Mechanistic Modeling Facilitate the Development of Tovetumab, a Monoclonal Antibody Directed Against Platelet-Derived Growth Factor Receptor Alpha, for Cancer Therapy. AAPS J. 2020 Nov 18;23(1):4. [Content Brief]
- [2]. Naomi Laing, et al. Inhibition of platelet-derived growth factor receptor α by MEDI-575 reduces tumor growth and stromal fibroblast content in a model of non-small cell lung cancer. Mol Pharmacol. 2013 Jun;83(6):1247-56. [Content Brief]
