1246086-78-1
1246086-78-1
Chemical Structure
VU 0364439
- CAS No.: 1246086-78-1
- Formula:C18H13Cl2N3O3S
- Molecular Weight:422.29
IUPAC Name: N-(3-chloro-4-(N-(2-chlorophenyl)sulfamoyl)phenyl)picolinamide
InChIKey: IXHCGJXBIHHIEF-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CC=C1)NC2=CC=C(S(=O)(NC3=CC=CC=C3Cl)=O)C(Cl)=C2
Biological Activity: VU 0364439 is a mGlu4 positive allosteric modulator with an EC50 of 19.8 nM. VU 0364439 modulates the GRM4/CBX4/HIF-1α signaling pathway by enhancing GRM4-CBX4 interaction. VU 0364439 can be used for the research of parkinson’s disease[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VU 0364439 | 99.42% | VU 0364439 is a mGlu4 positive allosteric modulator with an EC50 of 19.8 nM. VU 0364439 modulates the GRM4/CBX4/HIF-1α signaling pathway by enhancing GRM4-CBX4 interaction. VU 0364439 can be used for the research of parkinson’s disease. | ||||||||||||||||||||
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References
- [1]. Hong SP, et al. Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J Med Chem. 2011;54(14):5070-5081. [Content Brief]
- [2]. Zhang Z, et al. GRM4 inhibits the proliferation, migration, and invasion of human osteosarcoma cells through interaction with CBX4. Biosci Biotechnol Biochem. 2020;84(2):279-289. [Content Brief]
- [3]. Engers DW, et al. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorg Med Chem Lett. 2010;20(17):5175-5178. [Content Brief]
- [4]. Robichaud AJ, et al. Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics. ACS Chem Neurosci. 2011;2(8):433-449. [Content Brief]
