1246818-54-1
1246818-54-1
Chemical Structure
8-Hydroxyguanine hydrochloride
Synonym(s): 8-Oxoguanine hydrochloride; 8-oxo-Gua hydrochloride
- CAS No.: 1246818-54-1
- Formula:C5H6ClN5O2
- Molecular Weight:203.59
IUPAC Name: 2-amino-7,9-dihydro-3H-purine-6,8-dione hydrochloride
InChIKey: NZKRTEBHJIBRHK-UHFFFAOYSA-N
SMILES: O=C1NC(NC(N)=N2)=C(N1)C2=O.Cl
Biological Activity: 8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage[1][2].
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8-Hydroxyguanine hydrochloride | 8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage. | |||||||||||||||||||||
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References
- [1]. Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374(2):233-6. [Content Brief]
- [2]. Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel). 2023 Jun 19;12(6):1300. [Content Brief]
