1246820-06-3
1246820-06-3
Chemical Structure
4-Methylamino antipyrine-d3-1
- CAS No.: 1246820-06-3
- Formula:C12H12D3N3O
- Molecular Weight:220.29
IUPAC Name: 1,5-dimethyl-4-((methyl-d3)amino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
InChIKey: JILCEWWZTBBOFS-BMSJAHLVSA-N
SMILES: O=C1C(NC([2H])([2H])[2H])=C(N(N1C2=CC=CC=C2)C)C
Biological Activity: 4-Methylamino antipyrine-d3-1 is the deuterium labeled 4-Methylamino antipyrine-1. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever[1][2][3]. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Methylamino antipyrine-d3-1 | 4-Methylamino antipyrine-d3-1 is the deuterium labeled 4-Methylamino antipyrine-1. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties. | |||||||||||||||||||||
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4-Methylamino antipyrine (Standard) | ≥98% | 4-Methylamino antipyrine (Standard) is the analytical standard of 4-Methylamino antipyrine. This product is intended for research and analytical applications. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties. | ||||||||||||||||||||
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4-Methylamino antipyrine | 99.18% | 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties. | ||||||||||||||||||||
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Sulfamidopyrine sodium salt | 98.47% | Sulfamidopyrine (Melaminsulfone) sodium salt is an active compound. Sulfamidopyrine (sodium salt) can be used for analytical study. | ||||||||||||||||||||
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4-Formylaminoantipyrine (Standard) | ≥98% | 4-Formylaminoantipyrine (Standard) is the analytical standard of 4-Formylaminoantipyrine. This product is intended for research and analytical applications. 4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo. | ||||||||||||||||||||
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4-Methylamino antipyrine hydrochloride | 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties. | |||||||||||||||||||||
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Metamizole | Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity. | |||||||||||||||||||||
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Ramifenazone (Standard) | ≥98% | Ramifenazone (Isopropylaminoantipyrine) Standard is the analytical standard of Ramifenazone (HY-B1137). This product is intended for research and analytical applications. Ramifenazone (Isopropylaminoantipyrine) is a pyrazolone non-steroidal anti-inflammatory agent (NSAID) and a potent COX-2 inhibitor. Ramifenazone exhibits analgesic, antipyretic, anti-inflammatory, and antibacterial activities. Ramifenazone can be used for research on inflammation. | ||||||||||||||||||||
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Ramifenazone-d7 | Ramifenazone-d7 (Isopropylaminoantipyrine-d7) is the deuterated-labeled Ramifenazone (HY-B1137). Ramifenazone (Isopropylaminoantipyrine) is a pyrazolone non-steroidal anti-inflammatory agent (NSAID) and a potent COX-2 inhibitor. Ramifenazone exhibits analgesic, antipyretic, anti-inflammatory, and antibacterial activities. Ramifenazone can be used for research on inflammation. | |||||||||||||||||||||
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4-Aminoantipyrine hydrochloride | 95.0% | 4-Aminoantipyrine (hydrochloride) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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4-Acetylaminoantipyrine | 99.60% | 4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX). 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation. | ||||||||||||||||||||
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4-Acetylaminoantipyrine-d3 | 4-Acetylaminoantipyrine-d3 is the deuterium labeled 4-Acetylaminoantipyrine (HY-W268542). 4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX). 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation. | |||||||||||||||||||||
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References
- [1]. Burmańczuk A, et al. Pharmacokinetic investigations of the marker active metabolites 4-methylamino-antipyrine and 4-amino-antipyrine after intramuscular injection of metamizole in healthy piglets. J Vet Pharmacol Ther. 2016 Dec;39(6):616-620. [Content Brief]
- [2]. Ariza A, et al. Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole. Sci Rep. 2016 Mar 31;6:23845. [Content Brief]
- [3]. Campos C1, et al. Regulation of cyclooxygenase activity by metamizol. Eur J Pharmacol. 1999 Aug 13;378(3):339-47. [Content Brief]
