1246958-42-8
1246958-42-8
Chemical Structure
ASP7967 hemifumarate
- CAS No.: 1246958-42-8
- Formula:C24H20F2N8O4
- Molecular Weight:464.43
SMILES: OC(/C=C/C(O)=O)=O.FC(C=C1)=CC=C1NC2=NC(NC3=CC=C(C=C3)F)=NC(NCC4=NC=CC=N4)=N2.[1/2]
Biological Activity: ASP7967 hemifumarate is an orally active ligand of the RNA aptamer AC17-4 with a Kd of 12 nM. ASP7967 hemifumarate binds AC17-4 to regulate aptazyme-based and exon-skipping riboswitches, thereby enabling small-molecule-controlled transgene expression without exogenous protein factors. ASP7967 hemifumarate can be used for the study of synthetic RNA switches, gene expression regulation and AAV-based gene therapy-related expression control[1].
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ASP7967 hemifumarate | ASP7967 hemifumarate is an orally active ligand of the RNA aptamer AC17-4 with a Kd of 12 nM. ASP7967 hemifumarate binds AC17-4 to regulate aptazyme-based and exon-skipping riboswitches, thereby enabling small-molecule-controlled transgene expression without exogenous protein factors. ASP7967 hemifumarate can be used for the study of synthetic RNA switches, gene expression regulation and AAV-based gene therapy-related expression control. | |||||||||||||||||||||
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