124833-45-0
Chemical Structure
AP 811
- CAS No.: 124833-45-0
- Formula:C46H66N12O8
- Molecular Weight:915.09
IUPAC Name: (S)-3-((2S,3S)-2-((S)-2-(2-(4-(2-naphthamido)phenyl)acetamido)-5-guanidinopentanamido)-3-methylpentanamido)-4-(((S)-5-guanidino-1-(((S)-2-methylbutyl)amino)-1-oxopentan-2-yl)amino)-4-oxobutanoic acid
InChIKey: UNMJSSQZDQBGDS-OCFLPWLCSA-N
SMILES: NC(NCCC[C@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC(CC(C=C1)=CC=C1NC(C2=CC3=C(C=C2)C=CC=C3)=O)=O)CCCNC(N)=N)=O)[C@@H](C)CC)=O)=O)C(NC[C@@H](C)CC)=O)=N
Biological Activity: AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AP 811 | 99.64% | AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation. | ||||||||||||||||||||
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References
- [1]. Veale CA, et al. The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett. 2000;10(17):1949-1952. [Content Brief]
- [2]. William M, et al. Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am J Physiol Cell Physiol. 2008;294(4):C1067-C1073. [Content Brief]
