124857-59-6
Chemical Structure
Calphostin I
- CAS No.: 124857-59-6
- Formula:C44H38O15
- Molecular Weight:806.76
InChIKey: JKNIRLKHOOMGOJ-UHFFFAOYSA-N
SMILES: O=C(OC(CC1=C(C(C2=C(C=C(C(C3=C4C5=C(O)C=C3OC)=C2C1=C4C(CC(C)OC(C6=CC=C(C=C6)O)=O)=C(OC)C5=O)OC)O)=O)OC)C)OC7=CC=C(C=C7)O
Biological Activity: Calphostin I is a selective protein kinase C (PKC) inhibitor with an IC50 of 0.14 μM in rats. Calphostin I interacts with the regulatory domain of PKC, and the aromatic groups at its C-14 and C-17 positions contribute to enhanced potency and selectivity, with no inhibition of cyclic adenosine monophosphate-dependent protein kinase (PKA) at high concentrations. Calphostin I can be used in research related to cervical cancer and breast cancer[1].
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Calphostin I | Calphostin I is a selective protein kinase C (PKC) inhibitor with an IC50 of 0.14 μM in rats. Calphostin I interacts with the regulatory domain of PKC, and the aromatic groups at its C-14 and C-17 positions contribute to enhanced potency and selectivity, with no inhibition of cyclic adenosine monophosphate-dependent protein kinase (PKA) at high concentrations. Calphostin I can be used in research related to cervical cancer and breast cancer. | |||||||||||||||||||||
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