124916-54-7
124916-54-7
Chemical Structure
Celikalim
Synonym(s): Way 120491
- CAS No.: 124916-54-7
- Formula:C20H18F3NO4
- Molecular Weight:393.36
IUPAC Name: 2-((3S,4R)-3-hydroxy-2,2-dimethyl-6-(trifluoromethoxy)chroman-4-yl)isoindolin-1-one
InChIKey: ZORATYFUTXFLJS-SJORKVTESA-N
SMILES: O=C1N([C@H]2[C@H](O)C(C)(C)OC3=CC=C(OC(F)(F)F)C=C23)CC4=C1C=CC=C4
Biological Activity: Celikalim (Way 120491) is an antihypertensive agent. Celikalim lowers blood pressure through opening potassium channelsin vascular smooth muscle. Celikalim can inhibit white thrombus formation. Celikalim is a potent potassium opener in dog model. Celikalim can be studied in thrombosis-related research[1][2].
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Celikalim | Celikalim (Way 120491) is an antihypertensive agent. Celikalim lowers blood pressure through opening potassium channelsin vascular smooth muscle. Celikalim can inhibit white thrombus formation. Celikalim is a potent potassium opener in dog model. Celikalim can be studied in thrombosis-related research. | |||||||||||||||||||||
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References
- [1]. Patelunas-Hoffman, D. M., et al., (1994). Analysis of the potassium channel openers celikalim, pinacidil and cromakalim in platelet models of thrombosis. Thrombosis research, 74(5), 441-452. [Content Brief]
- [2]. de Lorenzi F. G. (1994). Celikalim (WAY-120491) increases K+ outward flux in dog and human airway smooth muscle. Pulmonary pharmacology, 7(2), 129-135. [Content Brief]
