125035-83-8
125035-83-8
Chemical Structure
7-Oxostaurosporine
Synonym(s): BMY-41950
- CAS No.: 125035-83-8
- Formula:C28H24N4O4
- Molecular Weight:480.51
IUPAC Name: (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9-tetrahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacene-14,16(15H)-dione
InChIKey: POTTVLREWUNNRO-UGZRAAABSA-N
SMILES: [H][C@@]12N3C4=C(C5=C(C6=C4C7=C3C=CC=C7)C(NC6=O)=O)N(C8=C5C=CC=C8)[C@](C)([C@@H]([C@@H](C2)NC)OC)O1
Biological Activity: 7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway[1][2].
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7-Oxostaurosporine | 7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway. | |||||||||||||||||||||
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References
- [1]. Masashi Maekawa, et al. Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine. Sci Rep. 2016 Nov 2;6:35762. [Content Brief]
- [2]. Feng Song, et al. The anticancer activity of carbazole alkaloids. Arch Pharm (Weinheim). 2022 Jan;355(1):e2100277. [Content Brief]
