1250849-11-6
Chemical Structure
TPI-1917-49
- CAS No.: 1250849-11-6
- Formula:C29H26N6O3S2
- Molecular Weight:570.69
IUPAC Name: 3-((4-(3-hydroxyphenyl)thiazol-2-yl)amino)-4-(4-(4-(3-hydroxyphenyl)thiazol-2-yl)piperazin-1-yl)benzamide
InChIKey: CZZOAECTXWFUKT-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(NC2=NC(C3=CC=CC(O)=C3)=CS2)=C1)N4CCN(CC4)C5=NC(C6=CC=CC(O)=C6)=CS5)N
Biological Activity: TPI-1917-49 is an agent that can cross the blood-brain barrier and reduce amyloid β (Aβ). TPI-1917-49 reduces the production of Aβ peptide segments by promoting the non-amyloidogenic pathway of amyloid precursor protein (APP) (increasing the generation of sAPPα mediated by α-secretase). TPI-1917-49 reduces amyloid plaques in mouse models. TPI-1917-49 can be used in Alzheimer's disease research[1].
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TPI-1917-49 | TPI-1917-49 is an agent that can cross the blood-brain barrier and reduce amyloid β (Aβ). TPI-1917-49 reduces the production of Aβ peptide segments by promoting the non-amyloidogenic pathway of amyloid precursor protein (APP) (increasing the generation of sAPPα mediated by α-secretase). TPI-1917-49 reduces amyloid plaques in mouse models. TPI-1917-49 can be used in Alzheimer's disease research. | |||||||||||||||||||||
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