125229-62-1
125229-62-1
Chemical Structure
DL-AP5 lithium
Synonym(s): 2-APV lithium; DL-2-Amino-5-phosphonovaleric acid lithium
- CAS No.: 125229-62-1
- Formula:C5H11LiNO5P
- Molecular Weight:203.06
IUPAC Name: lithium 2-amino-5-phosphonopentanoate
InChIKey: DHZMTARECLREHH-UHFFFAOYSA-M
SMILES: NC(CCCP(O)(O)=O)C(O[Li])=O
Biological Activity: DL-AP5 (2-APV) lithium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 lithium shows significantly antinociceptive activity. DL-AP5 lithium specifically blocks on channels in the rabbit retina[1][2][3].
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DL-AP5 lithium | DL-AP5 (2-APV) lithium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 lithium shows significantly antinociceptive activity. DL-AP5 lithium specifically blocks on channels in the rabbit retina. | |||||||||||||||||||||
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References
- [1]. Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185. [Content Brief]
- [2]. Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30. [Content Brief]
- [3]. Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169(1):120-7. [Content Brief]
