1253697-93-6
1253697-93-6
Chemical Structure
ABI-274
- CAS No.: 1253697-93-6
- Formula:C20H20N2O4
- Molecular Weight:352.38
IUPAC Name: (2-(p-tolyl)-1H-imidazol-5-yl)(3,4,5-trimethoxyphenyl)methanone
InChIKey: NQHVDNDKHQBFKP-UHFFFAOYSA-N
SMILES: COC1=CC(C(C2=CN=C(C3=CC=C(C=C3)C)N2)=O)=CC(OC)=C1OC
Biological Activity: ABI-274 is a tubulin and colchicine binding site inhibitor. ABI-274 significantly promotes cancer cell apoptosis in vitro when combined with vemurafenib (HY-12057). ABI-274 exhibits potent synergistic efficacy in the vemurafenib-resistant xenograft model in nude mice. ABI-274 can be studied in research on melanoma[1].
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ABI-274 | ABI-274 is a tubulin and colchicine binding site inhibitor. ABI-274 significantly promotes cancer cell apoptosis in vitro when combined with vemurafenib (HY-12057). ABI-274 exhibits potent synergistic efficacy in the vemurafenib-resistant xenograft model in nude mice. ABI-274 can be studied in research on melanoma. | |||||||||||||||||||||
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