1253919-92-4
Chemical Structure
CH5447240
- CAS No.: 1253919-92-4
- Formula:C26H39N5O4S
- Molecular Weight:517.68
IUPAC Name: 1-(3,5-dimethyl-4-(2-((2-((1r,4r)-4-methylcyclohexyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-2-en-8-yl)sulfonyl)ethyl)phenyl)-1-methylurea
InChIKey: PNTBFOBXKXSPLI-IRJFHVNHSA-N
SMILES: O=C(N)N(C1=CC(C)=C(CCS(=O)(N(CC2)CCC2(NC([C@H]3CC[C@H](C)CC3)=N4)C4=O)=O)C(C)=C1)C
Biological Activity: CH5447240 is an orally active agonist of parathyroid hormone receptor 1 (PTHR1). CH5447240 stimulates cAMP production in HKRK-B7 cells expressing hPTHR1, with an EC50 of 12 μM. CH5447240 exhibits PTH-like activity, elevating serum calcium and reducing serum phosphate. CH5447240 can be used for research on hypoparathyroidism[1][2].
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CH5447240 | CH5447240 is an orally active agonist of parathyroid hormone receptor 1 (PTHR1). CH5447240 stimulates cAMP production in HKRK-B7 cells expressing hPTHR1, with an EC50 of 12 μM. CH5447240 exhibits PTH-like activity, elevating serum calcium and reducing serum phosphate. CH5447240 can be used for research on hypoparathyroidism. | |||||||||||||||||||||
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References
- [1]. Nishimura Y, et al. Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small Molecule for Treatment of Hypoparathyroidism. Journal of medicinal chemistry. 2018 Jul 26;61(14):5949-5962. [Content Brief]
- [2]. Nishimura Y, et al. Lead Optimization and Avoidance of Reactive Metabolite Leading to PCO371, a Potent, Selective, and Orally Available Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist. Journal of medicinal chemistry. 2020 May 28;63(10):5089-5099. [Content Brief]
