1257317-77-3
1257317-77-3
Chemical Structure
SKLB70326
- CAS No.: 1257317-77-3
- Formula:C15H13N3O2S
- Molecular Weight:299.35
IUPAC Name: 3-amino-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
InChIKey: FEHLZYWXCFELFL-UHFFFAOYSA-N
SMILES: O=C(N)C1=C(C2=CC=C(N=C2S1)C3=CC=CC(OC)=C3)N
Biological Activity: SKLB70326 is a small molecule inhibitor of cell cycle progression that induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. SKLB70326 is involved in downregulating cyclin-dependent kinase (CDK) 2, CDK4, and CDK6, while also activating PARP, caspase-3, caspase-9, and Bax, and downregulating Bcl-2.
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SKLB70326 | SKLB70326 is a small molecule inhibitor of cell cycle progression that induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. SKLB70326 is involved in downregulating cyclin-dependent kinase (CDK) 2, CDK4, and CDK6, while also activating PARP, caspase-3, caspase-9, and Bax, and downregulating Bcl-2. | |||||||||||||||||||||
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