1258296-60-4
1258296-60-4
Chemical Structure
RO495
- CAS No.: 1258296-60-4
- Formula:C17H14Cl2N6O
- Molecular Weight:389.24
IUPAC Name: N-(2-((2-amino-6-methylpyrimidin-4-yl)amino)pyridin-4-yl)-2,6-dichlorobenzamide
InChIKey: LNGDQKGREFSTHB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(NC2=NC(N)=NC(C)=C2)=NC=C1)C3=C(Cl)C=CC=C3Cl
Biological Activity: RO495 is a potent inhibitor of non-receptor tyrosine-protein kinase 2 (TYK2 kinase)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RO495 | 98.59% | RO495 is a potent inhibitor of non-receptor tyrosine-protein kinase 2 (TYK2 kinase). | ||||||||||||||||||||
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Lck inhibitor 2 | 99.73% | Lck inhibitor 2 is a bisanilino pyrimidine-derived tyrosine kinase inhibitor targeting LCK, BTK, LYN, SYK and TXK, with a Kd value of 10 nM against TXK. | ||||||||||||||||||||
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TYK2 ligand 4 | TYK2 ligand 4 (Compound 2) is a TYK2 ligand. TYK2 ligand 4 binds to both the kinase domain and pseudokinase domain, and induces an inactive conformation of the kinase domain, thereby preventing ATP binding. TYK2 ligand 4 serves as a tool compound for the development of Deucravacitinib (HY-117287). | |||||||||||||||||||||
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2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide | 99.80% | GDC-046 is a potent, selective, and orally bioavailable TYK2 inhibitor with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively. | ||||||||||||||||||||
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MC3343 | 98.14% | MC3343, a DNMT inhibitor (EC50 of 5.7 μM) and a strong DNA binder, affects tumor proliferation by blocking OS cells in G1 or G2/M phases and induces osteoblastic differentiation through the specific re-expression of genes regulating this physiological process. | ||||||||||||||||||||
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Aumitin | 99.78% | Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively. | ||||||||||||||||||||
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SGI-1027 | 99.79% | SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate. | ||||||||||||||||||||
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ROS1-IN-1 | ROS1-IN-1 (Compound 31) is a potent and selective ROS1 kinase inhibitor with an IC50 of 0.097 μM. | |||||||||||||||||||||
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ZHSI-1 | ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that inhibits EV71/CVA16 replication and virus-induced pyroptosis associated with viral pathogenesis. ZHSI-1 effectively prevents EV71 infection in neonatal and young mice in animal models. ZHSI-1 can be used to study viral infections such as hand, foot and mouth disease (HFMD). | |||||||||||||||||||||
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TCJL37 | 99.89% | TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD). | ||||||||||||||||||||
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CEE321 | 98.74% | CEE321 is a potent pan-JAK inhibitor with an IC50 value of 54 nM. CEE321 potently inhibits biomarkers associated with atopic dermatitis. | ||||||||||||||||||||
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