1258494-60-8
1258494-60-8
Chemical Structure
TH1338
- CAS No.: 1258494-60-8
- Formula:C22H21N3O4
- Molecular Weight:391.42
IUPAC Name: (S)-5-amino-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
InChIKey: GDSWDKUWTYXXOX-QFIPXVFZSA-N
SMILES: O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC=CC=C5N=C4C3=C2N)=O
Biological Activity: TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TH1338 | 98.77% | TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile. | ||||||||||||||||||||
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Belotecan | 99.86% | Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer. | ||||||||||||||||||||
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Belotecan hydrochloride | 99.97% | Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative. | ||||||||||||||||||||
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SN-38 (Standard) | 99.76% | SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254). | ||||||||||||||||||||
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SN-38-13C6 | SN-38-13C6 (7-Ethyl-10-hydroxycamptothecin-13C6) is the 13C-labeled SN-38 (HY-13704). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254). | |||||||||||||||||||||
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Karenitecin | 98.02% | Karenitecin (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity. | ||||||||||||||||||||
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7-(2-Aminoethyl)camptothecin | 7-(2-Aminoethyl)camptothecin (7CPT) is a derivative of camptothecin that can be used to prepare TFO-CPT conjugates. | |||||||||||||||||||||
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XSJ110 | XSJ110 is a potent irreversible topoisomerase I (Topo I) inhibitor with an IC50 value of 0.133 μM. XSJ110 blocks DNA topoisomerization, induces DNA double-strand breaks, and triggers cell cycle arrest at G0/G1 phase, inducing tumor cell apoptosis. XSJ110 is promising for research of ampullary carcinoma (AC). | |||||||||||||||||||||
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7-Ethylcamptothecin | 99.58% | 7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a DNA topoisomerase I inhibitor that exhibits significant antitumor activity against tumor cells. 7-Ethylcamptothecin serves as a key precursor for the synthesis of 20 (S)-O-substituted benzoyl-7-ethylcamptothecin compounds. 7-Ethylcamptothecin is widely used in various tumor-related scientific studies. | ||||||||||||||||||||
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(Rac)-7-Ethyl-10-hydroxycamptothecin | (Rac)-7-Ethyl-10-hydroxycamptothecin is the derivative of (±)-10-Hydroxycamptothecin (HY-N0275). (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity. | |||||||||||||||||||||
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7-Ethylcamptothecin-d3-1 | 7-Ethylcamptothecin-d3-1 is the deuterium labeled 7-Ethylcamptothecin (HY-N2108). 7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a key intermediate in the synthesis of SN-38 (HY-13704). 7-Ethylcamptothecin can be used in tumor-related research. | |||||||||||||||||||||
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References
- [1]. Jian-Xin Duan, et al. 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment. J Med Chem. 2011 Mar 24;54(6):1715-23. [Content Brief]
- [2]. Xia Cheng, et al. Preparation, Characterization, and In Vivo Study of 7-Ethyl-14-Aminocamptothecin-Loaded Poly(Ethylene Glycol)2000 -Poly(Lactic Acid)2000 Polymeric Micelles Against H460 Human Nonsmall Cell Lung Carcinoma. J Pharm Sci. 2015 Nov;104(11):3934-3942. [Content Brief]
