125991-51-7
125991-51-7
Chemical Structure
TNP-351
- CAS No.: 125991-51-7
- Formula:C21H24N6O5
- Molecular Weight:440.45
IUPAC Name: (4-(3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl)benzoyl)-L-glutamic acid
InChIKey: WLGCEMWNUHSIIS-AWEZNQCLSA-N
SMILES: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CCCC2=CNC3=NC(N)=NC(N)=C32)C=C1)=O
Biological Activity: TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1].
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TNP-351 | TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo. | |||||||||||||||||||||
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