1259928-08-9
Chemical Structure
pJAK2(1001-1013)
- CAS No.: 1259928-08-9
- Formula:C76H118N17O26P
- Molecular Weight:1716.82
InChIKey: DQUKSZOMCGKGKS-YJDHHEDVSA-N
SMILES: O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N2[C@H](C(O)=O)CCC2)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H]3N(C([C@H](CC(C)C)N)=O)CCC3)=O)=O)=O)=O)=O)CC4=CC=C(OP(O)(O)=O)C=C4
Biological Activity: pJAK2(1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase and functions as a SOCS1/3antagonist. pJAK2 (1001-1013) blocks SOCS1-mediated negative regulation of immune function, and enhances the biological activity of cytokines such as IFNγ and IL6. pJAK2(1001-1013) inhibits the replication of a broad range of viruses and exerts dose-dependent protective efficacy against lethal viral infections. pJAK2(1001-1013) can be used for the study of immune regulation and infection[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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pJAK2(1001-1013) | 99.89% | pJAK2(1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase and functions as a SOCS1/3antagonist. pJAK2 (1001-1013) blocks SOCS1-mediated negative regulation of immune function, and enhances the biological activity of cytokines such as IFNγ and IL6. pJAK2(1001-1013) inhibits the replication of a broad range of viruses and exerts dose-dependent protective efficacy against lethal viral infections. pJAK2(1001-1013) can be used for the study of immune regulation and infection. | ||||||||||||||||||||
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References
- [1]. Ahmed CM, et al. SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function. Front Immunol. 2015 Apr 21;6:183. [Content Brief]
- [2]. Waiboci LW, et al. Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist. J Immunol. 2007 Apr 15;178(8):5058-68. [Content Brief]
- [3]. Ahmed CM, et al. A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus. Front Immunol. 2015 Nov 11;6:574. [Content Brief]
