126103-94-4
Chemical Structure
U 81749
- CAS No.: 126103-94-4
- Formula:C33H56N4O4
- Molecular Weight:572.82
InChIKey: RLQUQIUJPBZNMI-NFWZRYHXSA-N
SMILES: O=C(N[C@H](C(NCC1=NC=CC=C1)=O)[C@@H](C)CC)[C@H](C(C)C)C[C@H](O)[C@@H](NC(CC(C)(C)C)=O)CC2CCCCC2
Biological Activity: U 81749 is a competitive, reversible HIV-1 protease inhibitor with a Ki value of 70 nM. U 81749 inhibits HIV-1 protease within HIV-like particles, blocks the processing of the HIV-1 gag polyprotein p55 into the mature structural proteins p24 and p17, and thereby prevents viral maturation. U 81749 reduces HIV p24 and HIV RNA levels in acutely infected human lymphocytes, and shows no toxicity to lymphocyte proliferation at effective concentrations. U 81749 can be used in studies related to HIV-1 infection[1].
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U 81749 | U 81749 is a competitive, reversible HIV-1 protease inhibitor with a Ki value of 70 nM. U 81749 inhibits HIV-1 protease within HIV-like particles, blocks the processing of the HIV-1 gag polyprotein p55 into the mature structural proteins p24 and p17, and thereby prevents viral maturation. U 81749 reduces HIV p24 and HIV RNA levels in acutely infected human lymphocytes, and shows no toxicity to lymphocyte proliferation at effective concentrations. U 81749 can be used in studies related to HIV-1 infection. | |||||||||||||||||||||
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