1262034-38-7
1262034-38-7
Chemical Structure
Dacomitinib metabolite M1/2
- CAS No.: 1262034-38-7
- Formula:C27H32ClFN6O4S
- Molecular Weight:591.10
InChIKey: JACXJKYDLZNKQS-LFABVHOISA-N
SMILES: COC(C(NC(CC(SC[C@H](N)C(O)=O)CN1CCCCC1)=O)=C2)=CC3=C2C(NC4=CC(Cl)=C(C=C4)F)=NC=N3
Biological Activity: Dacomitinib metabolite M1/2 is a potent inhibitor of both wild-type (WT) EGFR and the T790M mutation, demonstrating significant activity against acquired resistance mechanisms in EGFR-mutant non-small-cell lung cancer (NSCLC).
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Dacomitinib metabolite M1/2 | Dacomitinib metabolite M1/2 is a potent inhibitor of both wild-type (WT) EGFR and the T790M mutation, demonstrating significant activity against acquired resistance mechanisms in EGFR-mutant non-small-cell lung cancer (NSCLC). | |||||||||||||||||||||
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