1268163-15-0
1268163-15-0
Chemical Structure
TL8-506
- CAS No.: 1268163-15-0
- Formula:C20H17N3O2
- Molecular Weight:331.37
IUPAC Name: ethyl 2-amino-8-(3-cyanophenyl)-3H-benzo[b]azepine-4-carboxylate
InChIKey: YHRYTTWRVKXODS-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC=C(C3=CC=CC(C#N)=C3)C=C2N=C(N)C1)OCC
Biological Activity: TL8-506 is a specific TLR8 agonist with an EC50 of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TL8-506 | 95.0% | TL8-506 is a specific TLR8 agonist with an EC50 of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy. | ||||||||||||||||||||
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TL8-506 (GMP) | TL8-506 (GMP) is TL8-506 (HY-20457) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TL8-506 is a specific TLR8 agonist with an EC50 of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy. | |||||||||||||||||||||
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References
- [1]. Jun Tang, et al. Toll-Like Receptor 8 Agonist Strengthens the Protective Efficacy of ESAT-6 Immunization to Mycobacterium tuberculosis Infection. Front Immunol. 2018 Jan 24;8:1972. [Content Brief]
- [2]. He M, S, et al. Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells. J Immunother Cancer. 2022 Jun;10(6):e004268. [Content Brief]
