1270084-92-8
1270084-92-8
Chemical Structure
APX-115 free base
Synonym(s): Ewha-18278 free base; Isuzinaxib free base
- CAS No.: 1270084-92-8
- Formula:C17H17N3O
- Molecular Weight:279.34
IUPAC Name: 3-phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol
InChIKey: LQKQLKMTJOMCMJ-UHFFFAOYSA-N
SMILES: OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3
Biological Activity: APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].
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APX-115 free base | 99.54% | APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury. | ||||||||||||||||||||
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