127245-22-1
127245-22-1
Chemical Structure
BF389
Synonym(s): Biofor 389
- CAS No.: 127245-22-1
- Formula:C20H29NO3
- Molecular Weight:331.45
IUPAC Name: (E)-4-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-methyl-1,2-oxazinan-3-one
InChIKey: BWRYNNCGEDOTRW-GXDHUFHOSA-N
SMILES: CC(C)(C1=C(C(C(C)(C)C)=CC(/C=C2C(N(OCC/2)C)=O)=C1)O)C
Biological Activity: BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC50s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research[1][2][3].
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BF389 | BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC50s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research. | |||||||||||||||||||||
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References
- [1]. Bendele AM, et al. Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis. J Pharmacol Exp Ther. 1992 Jan;260(1):300-5. [Content Brief]
- [2]. Wong S, et al. Antiarthritic profile of BF-389--a novel anti-inflammatory agent with low ulcerogenic liability. Agents Actions. 1992 Sep;37(1-2):90-8. [Content Brief]
- [3]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [Content Brief]
