127279-06-5
Chemical Structure
BN-50726
- CAS No.: 127279-06-5
- Formula:C34H48ClN5O2S2
- Molecular Weight:658.36
IUPAC Name: 6-(2-chlorophenyl)-9-(hexadecylsulfonyl)-1-methyl-7,8,9,10-tetrahydro-4H-pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
InChIKey: XYNVFDKKFDLTPP-UHFFFAOYSA-N
SMILES: CC1=NN=C2N1C3=C(C4=C(CN(S(=O)(CCCCCCCCCCCCCCCC)=O)CC4)S3)C(C5=CC=CC=C5Cl)=NC2
Biological Activity: BN-50726 is a potent platelet-activating factor (PAF) receptor antagonist. BN-50726 inhibits PAF-induced effects (e.g., [3H]-serotonin release and hypotension) (IC50=5.40 nM). BN-50726 is promising for research of PAF-mediated pathological processes (e.g., inflammation, anaphylaxis, hypotension)[1][2].
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BN-50726 | BN-50726 is a potent platelet-activating factor (PAF) receptor antagonist. BN-50726 inhibits PAF-induced effects (e.g., [3H]-serotonin release and hypotension) (IC50=5.40 nM). BN-50726 is promising for research of PAF-mediated pathological processes (e.g., inflammation, anaphylaxis, hypotension). | |||||||||||||||||||||
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References
- [1]. Zarco P, et al. Involvement of platelet-activating factor and tumour necrosis factor in the pathogenesis of joint inflammation in rabbits. Clin Exp Immunol. 1992 May;88(2):318-23. [Content Brief]
- [2]. Yue TL, et al. Pharmacologic profile of BN 50739, a new PAF antagonist in vitro and in vivo. Prostaglandins. 1990 May;39(5):469-80. [Content Brief]
