1275996-50-3
Chemical Structure
KRP-109
- CAS No.: 1275996-50-3
- Formula:C26H30N4O7
- Molecular Weight:510.54
IUPAC Name: (S)-2-(2-(3-(dimethylamino)pyrrolidin-1-yl)pyridin-3-yl)-5-ethyl-7-methoxy-4H-benzo[d][1,3]oxazin-4-one maleate
InChIKey: YLFBWXUNSRKFNI-DASCVMRKSA-N
SMILES: OC(/C=C\C(O)=O)=O.CCC1=C2C(N=C(C3=C(N4C[C@H](CC4)N(C)C)N=CC=C3)OC2=O)=CC(OC)=C1
Biological Activity: KRP-109 is a neutrophil elastase (NE) inhibitor with activity in reducing lung inflammation. KRP-109 improves survival in mouse models and reduces the number of neutrophils and inflammation in the alveolar walls. KRP-109 significantly reduced cell and neutrophil counts in bronchoalveolar lavage fluid, as well as cytokine levels such as interleukin 1β and macrophage inflammatory protein 2. KRP-109 can be used in the research of severe pneumonia[1].
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KRP-109 | KRP-109 is a neutrophil elastase (NE) inhibitor with activity in reducing lung inflammation. KRP-109 improves survival in mouse models and reduces the number of neutrophils and inflammation in the alveolar walls. KRP-109 significantly reduced cell and neutrophil counts in bronchoalveolar lavage fluid, as well as cytokine levels such as interleukin 1β and macrophage inflammatory protein 2. KRP-109 can be used in the research of severe pneumonia. | |||||||||||||||||||||
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