127902-33-4
Chemical Structure
A71378
- CAS No.: 127902-33-4
- Formula:C48H62N8O13S
- Molecular Weight:991.12
IUPAC Name: (3S,6S,9S,15S)-9-((1H-indol-3-yl)methyl)-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-6,15-dibutyl-4-methyl-5,8,11,14,17-pentaoxo-19-(4-(sulfooxy)phenyl)-4,7,10,13,16-pentaazanonadecanoic acid
InChIKey: YJRSAZMDFOJHLB-HECCNADXSA-N
SMILES: NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)N(C)C([C@H](CCCC)NC([C@@H](NC(CNC([C@H](CCCC)NC(CCC2=CC=C(C=C2)OS(=O)(O)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O
Biological Activity: A71378 is a selectivity CCK-A receptor agonist the IC50 values of 0.4 nM, 300 nM, and 1,200 nM for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor, respectively. A71378 elicits pancreatic amylase secretion (EC50 = 0.16 nM) and ileal muscle contraction (EC50 = 3.7 nM)[1].
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A71378 | A71378 is a selectivity CCK-A receptor agonist the IC50 values of 0.4 nM, 300 nM, and 1,200 nM for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor, respectively. A71378 elicits pancreatic amylase secretion (EC50 = 0.16 nM) and ileal muscle contraction (EC50 = 3.7 nM). | |||||||||||||||||||||
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