1279026-89-9
Chemical Structure
VAP-1-IN-2
- CAS No.: 1279026-89-9
- Formula:C25H27ClN6O3
- Molecular Weight:494.98
IUPAC Name: 4-(4-(5-(3-((2-amino-N-methylacetamido)methyl)phenyl)pyrimidin-2-yl)piperazin-1-yl)-3-chlorobenzoic acid
InChIKey: WUPBTBRKQPXTEW-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(C(Cl)=C1)N2CCN(C=3N=CC(=CN3)C4=CC=CC(=C4)CN(C(=O)CN)C)CC2
Biological Activity: VAP-1-IN-2 is an orally active VAP-1 inhibitor with an IC50 value of 0.025 μM against human VAP-1 and 0.015 μM against rat VAP-1. VAP-1-IN-2 inhibits urinary protein excretion and the progression of proteinuria in diabetic rats. VAP-1-IN-2 inhibits VAP-1 activity in rats. VAP-1-IN-2 can be used in research related to diabetes and nephropathy[1][2].
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VAP-1-IN-2 | VAP-1-IN-2 is an orally active VAP-1 inhibitor with an IC50 value of 0.025 μM against human VAP-1 and 0.015 μM against rat VAP-1. VAP-1-IN-2 inhibits urinary protein excretion and the progression of proteinuria in diabetic rats. VAP-1-IN-2 inhibits VAP-1 activity in rats. VAP-1-IN-2 can be used in research related to diabetes and nephropathy. | |||||||||||||||||||||
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References
- [1]. Yamaki S, et al. Synthesis and structure activity relationships of carbamimidoylcarbamate derivatives as novel vascular adhesion protein-1 inhibitors. Bioorg Med Chem. 2017 Nov 1;25(21):6024-6038. [Content Brief]
- [2]. Yamaki S, et al. Synthesis and pharmacological evaluation of glycine amide derivatives as novel vascular adhesion protein-1 inhibitors without CYP3A4 and CYP2C19 inhibition. Bioorg Med Chem. 2017 Aug 1;25(15):4110-4122. [Content Brief]
