12798-57-1
12798-57-1
Chemical Structure
Procyanidin B5
- CAS No.: 12798-57-1
- Formula:C30H26O12
- Molecular Weight:578.52
IUPAC Name: (2R,2'R,3R,3'R,4S)-2,2'-bis(3,4-dihydroxyphenyl)-[4,6'-bichromane]-3,3',5,5',7,7'-hexaol
InChIKey: GMISZFQPFDAPGI-CVJZBMGUSA-N
SMILES: O[C@@H]1[C@@H](C2=C(O)C=C(O[C@H](C3=CC(O)=C(C=C3)O)[C@@H](C4)O)C4=C2O)C5=C(O)C=C(O)C=C5O[C@@H]1C6=CC(O)=C(C=C6)O
Biological Activity: Procyanidin B5 is an antioxidant with a IC50 of 0.1 mM in lipid peroxidation assays using mouse liver homogenates. Procyanidin B5 scavenges superoxide anions and hydroxyl radicals, and inhibits lipid peroxidation. Procyanidin B5 can be used in research related to cardiovascular diseases, cancer, and malaria[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Procyanidin B5 | 97.06% | Procyanidin B5 is an antioxidant with a IC50 of 0.1 mM in lipid peroxidation assays using mouse liver homogenates. Procyanidin B5 scavenges superoxide anions and hydroxyl radicals, and inhibits lipid peroxidation. Procyanidin B5 can be used in research related to cardiovascular diseases, cancer, and malaria. | ||||||||||||||||||||
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Procyanidol B4 (Standard) | ≥98% | Procyanidol B4 (Standard) is the analytical standard of Procyanidol B4 (HY-107208). This product is intended for research and analytical applications. Procyanidol B4 ((-)-Procyanidin B4) is an orally active polyphenol found in Q.gilva. Procyanidol B4 exerts antioxidant activity by scavenging DPPH (HY-112053) (IC50: 12.15 μM) and Nitro blue tetrazolium chloride (NBT) (HY-15925) (IC50: 8.67 μM). Procyanidol B4 exhibits anti-inflammatory activity by inhibiting the expression of COX-2 and IL-1β and iNOS . | ||||||||||||||||||||
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Afzelechin-(4α→8)-epiafzelechin | Afzelechin-(4α→8)-epiafzelechin is a Flavonoids product that can be isolated from the herbs of Cassia javanica. | |||||||||||||||||||||
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Neuroprotective agent 11 | Neuroprotective agent 11 (Compound 1a) is an orally active polyphenol compound with significant protective effects against cerebral ischemia. The main activities of Neuroprotective agent 11 include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarction volume, and improving behavioral symptoms of cerebral ischemic mice. Neuroprotective agent 11 exerts its regulatory mechanism by downregulating the expression of inflammatory factors (iNOS、COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 can be used in the study of cerebral ischemia-related diseases (such as ischemic stroke). | |||||||||||||||||||||
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Procyanidin B1 (Standard) | ≥98% | Procyanidin B1 (Standard) is the analytical standard of Procyanidin B1. This product is intended for research and analytical applications. Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity. | ||||||||||||||||||||
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Procyanidin B2 | 99.89% | Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities. | ||||||||||||||||||||
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Procyanidin A5' | Procyanidin A5' is A dimerized proanthocyanidin type A. | |||||||||||||||||||||
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Procyanidin A1 (Standard) | ≥98% | Procyanidin A1 (Standard) is the analytical standard of Procyanidin A1. This product is intended for research and analytical applications. Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects. | ||||||||||||||||||||
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Procyanidin B3 (Standard) | ≥98% | Procyanidin B3 (Standard) is the analytical standard of Procyanidin B3. This product is intended for research and analytical applications. Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis. | ||||||||||||||||||||
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Proanthocyanidin A4 (Standard) | ≥98% | Proanthocyanidin A4 (Standard) is the analytical standard of Proanthocyanidin A4. This product is intended for research and analytical applications. Proanthocyanidin A4 is a polyphenol found in a variety of plants. Proanthocyanidin A4 possesses anti-inflammatory effects. | ||||||||||||||||||||
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Prodelphinidin B3 | Prodelphinidin B3 is a proanthocyanidin compound that exhibits significant anti-tumor activity. Prodelphinidin B3 induces cell cycle arrest at the G1/G0 phase in PC-3 cells, activates caspase-3, and promotes apoptosis. Prodelphinidin B3 can induce the differentiation of leukemia cells and synergistically enhance retinoic acid (HY-14649)-induced granulocytic differentiation and sodium butyrate (HY-B0350A)-induced monocytic differentiation in HL-60 cells. Prodelphinidin B3 also possesses antioxidant activity. Prodelphinidin B3 is used in research on prostate cancer and leukemia. | |||||||||||||||||||||
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References
- [1]. Wang JN, et al. Antioxidant activity of polyphenols from seeds of Vitis amurensis in vitro. Acta Pharmacol Sin. 2000;21(7):633-636. [Content Brief]
- [2]. Jurikova T, et al. Polyphenolic profile and biological activity of Chinese hawthorn (Crataegus pinnatifida BUNGE) fruits. Molecules. 2012;17(12):14490-14509. Published 2012 Dec 6. [Content Brief]
