1281683-44-0
Chemical Structure
dCeMM4
- CAS No.: 1281683-44-0
- Formula:C14H15N3O3S2
- Molecular Weight:337.42
InChIKey: BPWZJVKIVHVVHP-UHFFFAOYSA-N
SMILES: CC1=CC=C(O1)C(N2CSCC2C(/N=C3NC=C(S/3)C)=O)=O
Biological Activity: dCeMM4 is a Cyclin K Molecular glue degrader. dCeMM4 mediates the direct interaction between CDK12:cyclin K and the CRL4B ligase complex, thereby driving the ubiquitination and proteasomal degradation of Cyclin K. dCeMM4 induces Apoptosis without cell cycle phase-specific arrest. dCeMM4 exhibits synergistic activity with DNA damage inducers, and a correlation exists between Cyclin K degradation and cellular sensitivity. dCeMM4 can be used in studies related to T-cell malignancies[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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dCeMM4 | 98.01% | dCeMM4 is a Cyclin K Molecular glue degrader. dCeMM4 mediates the direct interaction between CDK12:cyclin K and the CRL4B ligase complex, thereby driving the ubiquitination and proteasomal degradation of Cyclin K. dCeMM4 induces Apoptosis without cell cycle phase-specific arrest. dCeMM4 exhibits synergistic activity with DNA damage inducers, and a correlation exists between Cyclin K degradation and cellular sensitivity. dCeMM4 can be used in studies related to T-cell malignancies. | ||||||||||||||||||||
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References
- [1]. Jochem M, et al. Degradome analysis to identify direct protein substrates of small-molecule degraders. Cell chemical biology. 2025 Jan 16;32(1):192-200.e6. [Content Brief]
- [2]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling. Nature chemical biology. 2020 Nov;16(11):1199-1207. [Content Brief]
