1284150-65-7
Chemical Structure
Azeliragon dihydrochloride
Synonym(s): TTP488 dihydrochloride; PF-04494700 dihydrochloride
- CAS No.: 1284150-65-7
- Formula:C32H40Cl3N3O2
- Molecular Weight:605.04
IUPAC Name: 3-(4-(2-butyl-1-(4-(4-chlorophenoxy)phenyl)-1H-imidazol-4-yl)phenoxy)-N,N-diethylpropan-1-amine dihydrochloride
InChIKey: CQAGJWKITXAOAM-UHFFFAOYSA-N
SMILES: CCN(CCCOC1=CC=C(C=C1)C2=CN(C(CCCC)=N2)C3=CC=C(C=C3)OC4=CC=C(C=C4)Cl)CC.Cl.Cl
Biological Activity: Azeliragon dihydrochloride (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD)[1]. Azeliragon dihydrochloride also can cross the blood-brain barrier (BBB)[2].
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Azeliragon dihydrochloride | Azeliragon dihydrochloride (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD). Azeliragon dihydrochloride also can cross the blood-brain barrier (BBB). | |||||||||||||||||||||
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References
- [1]. Bongarzone S, et al. Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective. J Med Chem. 2017 Sep 14;60(17):7213-7232. [Content Brief]
- [2]. Burstein AH, et al. Assessment of Azeliragon QTc Liability Through Integrated, Model-Based Concentration QTc Analysis. Clin Pharmacol Drug Dev. 2019 May;8(4):426-435. [Content Brief]
