128420-61-1
128420-61-1
Chemical Structure
Minopafant
Synonym(s): E 5880
- CAS No.: 128420-61-1
- Formula:C46H73ClN4O9
- Molecular Weight:861.55
IUPAC Name: (R)-1-ethyl-2-((2-methoxy-N-((2-methoxy-3-((4-((octadecylcarbamoyl)oxy)piperidine-1-carbonyl)oxy)propoxy)carbonyl)benzamido)methyl)pyridin-1-ium chloride
InChIKey: IXRMFSBOHHRXSS-YPMTVOEDSA-N
SMILES: O=C(C1=C(C=CC=C1)OC)N(C(OC[C@H](OC)COC(N2CCC(CC2)OC(NCCCCCCCCCCCCCCCCCC)=O)=O)=O)CC3=CC=CC=[N+]3CC.[Cl-]
Biological Activity: Minopafant (E 5880) is a PAF receptor antagonist. Minopafant can be used in studies of cerebral vasospasm following subarachnoid hemorrhage[1][2].
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Minopafant | Minopafant (E 5880) is a PAF receptor antagonist. Minopafant can be used in studies of cerebral vasospasm following subarachnoid hemorrhage. | |||||||||||||||||||||
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References
- [1]. Hirashima Y, et al. Prevention of cerebrovasospasm following subarachnoid hemorrhage in rabbits by the platelet-activating factor antagonist, E5880[J]. Journal of neurosurgery, 1996, 84(5): 826-830.
- [2]. Hirashima Y, et al. Effect of a platelet-activating factor receptor antagonist, E5880, on cerebral vasospasm after aneurysmal subarachnoid hemorrhage--open clinical trial to investigate efficacy and safety. Neurol Med Chir (Tokyo). 2001 Apr;41(4):165-75; discussion 175-6. [Content Brief]
