128533-02-8
Chemical Structure
Sauristolactam
Synonym(s): Saurolactam
- CAS No.: 128533-02-8
- Formula:C17H13NO3
- Molecular Weight:279.29
IUPAC Name: 2-hydroxy-1-methoxy-5-methyldibenzo[cd,f]indol-4(5H)-one
InChIKey: WRFZNTLPRUIGKH-UHFFFAOYSA-N
SMILES: O=C1N(C2=C3C1=CC(O)=C(C3=C4C(C=CC=C4)=C2)OC)C
Biological Activity: Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells[1]. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation[2].
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Sauristolactam | Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. | |||||||||||||||||||||
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References
- [1]. Kim SR, et al. Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production. Planta Med. 2004 May;70(5):391-6. [Content Brief]
- [2]. Li Z, et al. Saurolactam Inhibits Proliferation, Migration, and Invasion of Human Osteosarcoma Cells. Cell Biochem Biophys. 2015 Jul;72(3):719-26. [Content Brief]
