1286279-90-0
Chemical Structure
Antifolate C2
- CAS No.: 1286279-90-0
- Formula:C19H21N5O6S
- Molecular Weight:447.46
IUPAC Name: (5-(3-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl)thiophene-3-carbonyl)-L-glutamic acid
InChIKey: RMEHPWHLFJJYTB-ZDUSSCGKSA-N
SMILES: O=C1C2=C(NC(N)=N1)NC(CCCC3=CC(C(N[C@H](C(O)=O)CCC(O)=O)=O)=CS3)=C2
Biological Activity: Antifolate C2 is an anti-folate compound that has inhibitory effects on the proliferation of non-squamous non-small cell lung cancer (NS-NSCLC). Antifolate C2 achieves tumor selectivity by targeting proton-coupled folate transporter (PCFT), which is more selective to PCFT than the commonly used anti-folate drug Pemetrexed (HY-10820). Antifolate C2 blocks the biosynthesis of deoxypurine nucleotides by inhibiting glycinamide ribonucleotide formyltransferase (GARFTase), ultimately inhibiting the proliferation of tumor cells. Antifolate C2 can be used in studies of NS-NSCLC, especially in patients who do not respond well to Pemetrexed[1].
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Antifolate C2 | Antifolate C2 is an anti-folate compound that has inhibitory effects on the proliferation of non-squamous non-small cell lung cancer (NS-NSCLC). Antifolate C2 achieves tumor selectivity by targeting proton-coupled folate transporter (PCFT), which is more selective to PCFT than the commonly used anti-folate drug Pemetrexed (HY-10820). Antifolate C2 blocks the biosynthesis of deoxypurine nucleotides by inhibiting glycinamide ribonucleotide formyltransferase (GARFTase), ultimately inhibiting the proliferation of tumor cells. Antifolate C2 can be used in studies of NS-NSCLC, especially in patients who do not respond well to Pemetrexed. | |||||||||||||||||||||
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