128857-77-2
128857-77-2
Chemical Structure
Cyclo(GRGDSPA)
- CAS No.: 128857-77-2
- Formula:C25H40N10O10
- Molecular Weight:640.65
InChIKey: FWFZEPRYKXWBLR-QXKUPLGCSA-N
SMILES: O=C1N2[C@@](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H]1CO)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)=O)C)=O)([H])CCC2
Biological Activity: Cyclo(GRGDSPA) is a cyclic RGD peptide targeting αvβ3 integrin. Cyclo(GRGDSPA) reduces the formation of colonies in mice injected with B16-FE7 melanoma cells. Cyclo(GRGDSPA) can be used for melanoma research[1][2].
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Cyclo(GRGDSPA) | Cyclo(GRGDSPA) is a cyclic RGD peptide targeting αvβ3 integrin. Cyclo(GRGDSPA) reduces the formation of colonies in mice injected with B16-FE7 melanoma cells. Cyclo(GRGDSPA) can be used for melanoma research. | |||||||||||||||||||||
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References
- [1]. Hazenbiller O, et al. Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide. BMC Cell Biol. 2017 Nov 14;18(1):32. [Content Brief]
- [2]. Kumagai H, et al. Effect of cyclic RGD peptide on cell adhesion and tumor metastasis. Biochem Biophys Res Commun. 1991 May 31;177(1):74-82. [Content Brief]
