129445-88-1
Chemical Structure
ES-8891
- CAS No.: 129445-88-1
- Formula:C42H60N6O6S
- Molecular Weight:777.03
IUPAC Name: (3S,4S)-5-cyclohexyl-N-hexyl-3-hydroxy-4-((S)-2-((S)-2-(2-morpholinoacetamido)-3-(naphthalen-1-yl)propanamido)-3-(thiazol-4-yl)propanamido)pentanamide
InChIKey: SYPWPWUSXPWLKW-ZQWQDMLBSA-N
SMILES: O=C(NCCCCCC)C[C@H](O)[C@@H](NC([C@@H](NC([C@@H](NC(CN1CCOCC1)=O)CC2=C3C=CC=CC3=CC=C2)=O)CC4=CSC=N4)=O)CC5CCCCC5
Biological Activity: ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis[1].
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ES-8891 | ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis. | |||||||||||||||||||||
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