129623-01-4
Chemical Structure
GR 82334
- CAS No.: 129623-01-4
- Formula:C69H91N15O16
- Molecular Weight:1386.55
IUPAC Name: (S)-4-((S)-2-(((S)-4-amino-1-(((S)-6-amino-1-(((S)-1-(((S)-1-((S)-7-((S)-1-(((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxohexan-2-yl)amino)-1,4-dioxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-4-oxo-3-((S)-2-((S)-5-oxopyrrolidine-2-carboxamido)propanamido)butanoic acid
InChIKey: KWECNVXXONDEKG-JTCMYMKESA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H]2N(CCC2)C([C@H](CC(O)=O)NC([C@H](C)NC([C@@H]3CCC(N3)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)C(N5[C@]6(CCC5)C(N(CC6)[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC7=CNC8=CC=CC=C78)=O)=O)=O
Biological Activity: GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1].
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GR 82334 | GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats. | |||||||||||||||||||||
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