129981-36-8
129981-36-8
Chemical Structure
Sampatrilat
Synonym(s): UK-81252
- CAS No.: 129981-36-8
- Formula:C26H40N4O9S
- Molecular Weight:584.68
IUPAC Name: (S)-3-((S)-6-amino-2-(methylsulfonamido)hexanamido)-2-((1-(((S)-1-carboxy-2-(4-hydroxyphenyl)ethyl)carbamoyl)cyclopentyl)methyl)propanoic acid
InChIKey: LPUDGHQMOAHMMF-JBACZVJFSA-N
SMILES: OC([C@H](CNC([C@@H](NS(C)(=O)=O)CCCCN)=O)CC1(CCCC1)C(N[C@H](C(O)=O)CC2=CC=C(O)C=C2)=O)=O
Biological Activity: Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sampatrilat | 99.22% | Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation. | ||||||||||||||||||||
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Thymopentin | 99.95% | Thymopentin is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs). | ||||||||||||||||||||
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Thymopentin acetate (Standard) | ≥98% | Thymopentin (acetate) (Standard) is the analytical standard of Thymopentin (acetate) (HY-N7122A). This product is intended for research and analytical applications. Thymopentin acetate is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin acetate is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin acetate enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs). | ||||||||||||||||||||
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STAT3-IN-22, negative control | STAT3-IN-22, negative control (PYLKTK) is a peptide that serves as a control peptide for phosphotyrosine. | |||||||||||||||||||||
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Angiotensin II (1-4), human | Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. | |||||||||||||||||||||
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Acetyl pentapeptide-1 | Acetyl pentapeptide-1 is a pentapeptide. Acetyl pentapeptide-1 combined with other oligopeptides can enhance the skin barrier function. | |||||||||||||||||||||
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Acetyl tetrapeptide-2 | 99.36% | Acetyl tetrapeptide-2 is a bio-active peptide that exhibits anti-aging activity. Acetyl tetrapeptide-2 can reduce loss of thymic factors. Acetyl tetrapeptide-2 can increase the stiffness of HaCaT cells. Acetyl tetrapeptide-2 is a stimulator of structural skin elements including collagen and elastin. | ||||||||||||||||||||
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Ac-Tyr-Val-Lys-Asp-aldehyde | 99.89% | Ac-Tyr-Val-Lys-Asp-aldehyde is a reversible caspase-1 inhibitor. Ac-Tyr-Val-Lys-Asp-aldehyde increases GATA1 levels by inhibiting caspase-1 and promotes erythroid differentiation. can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia. | ||||||||||||||||||||
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Ac-Val-Tyr-Lys-NH2 | Ac-Val-Tyr-Lys-NH2 is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development. | |||||||||||||||||||||
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Glu-Thr-Tyr-Ser-Lys | Glu-Thr-Tyr-Ser-Lys is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development. | |||||||||||||||||||||
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L-Lysyl-L-tyrosine-α-L-lysine | L-Lysyl-L-tyrosine-α-L-lysine is a lysine derivative. | |||||||||||||||||||||
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References
- [1]. Sharma RK, et al. The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme. J Chem Inf Model. 2016 Dec 27;56(12):2486-2494. [Content Brief]
- [2]. Maki T, et al. Beneficial effects of sampatrilat, a novel vasopeptidase inhibitor, on cardiac remodeling and function of rats with chronic heart failure following left coronary artery ligation.J Pharmacol Exp Ther. 2003 Apr;305(1):97-105. [Content Brief]
