13018-54-7
Chemical Structure
FAICAR
Synonym(s): 5-Formamidoimidazole-4-carboxamide ribotide
- CAS No.: 13018-54-7
- Formula:C10H15N4O9P
- Molecular Weight:366.22
IUPAC Name: ((2R,3S,4R,5R)-5-(4-carbamoyl-5-formamido-1H-imidazol-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
InChIKey: ABCOOORLYAOBOZ-KQYNXXCUSA-N
SMILES: O=C(C1=C(NC=O)N([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C=N1)N
Biological Activity: FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and the IMP cyclohydrolase substrate of Cryptococcus neoformans ATIC. It is a key intermediate in the de novo purine synthesis pathway. FAICAR can be used in studies related to Cryptococcus neoformans infection[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FAICAR | 85.0% | FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and the IMP cyclohydrolase substrate of Cryptococcus neoformans ATIC. It is a key intermediate in the de novo purine synthesis pathway. FAICAR can be used in studies related to Cryptococcus neoformans infection. | ||||||||||||||||||||
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References
- [1]. Wizrah MSI, et al. AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. J Biol Chem. 2022;298(10):102453. [Content Brief]
- [2]. Szabados E, et al. Radioassay of bifunctional 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase by thin-layer chromatography. Anal Biochem. 1994;221(2):401-404. [Content Brief]
- [3]. Vergis JM, et al. Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase. Biochemistry. 2004;43(5):1184-1192. [Content Brief]
