1309935-98-5
Chemical Structure
6-Sulfatoxymelatonin-d4
- CAS No.: 1309935-98-5
- Formula:C13H12D4N2O6S
- Molecular Weight:332.37
IUPAC Name: methyl-d3 2-methylbutanoate
InChIKey: QQEILXDLZRLTME-KHORGVISSA-N
SMILES: CC(NC([2H])([2H])C([2H])([2H])C(C1=C2)=CNC1=CC(OS(=O)(O)=O)=C2OC)=O
Biological Activity: 6-Sulfatoxymelatonin-d4 is the deuterated-labeled 6-Sulfatoxymelatonin. 6-Sulfatoxymelatonin is a metabolite of Melatonin (HY-B0075) and serves as a detection marker for Melatonin. 6-Sulfatoxymelatonin shows a decreasing trend with increasing age, and its urinary excretion is closely correlated with plasma Melatonin levels, which can reflect changes in the secretion phase of melatonin. 6-Sulfatoxymelatonin is associated with reduced risks of diabetic retinopathy and coronary heart disease, and can act as a biomarker for microvascular and macrovascular complications of type 2 diabetes mellitus. 6-Sulfatoxymelatonin can be used in studies related to type 2 diabetes mellitus and coronary heart disease[1][2][3][4].
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6-Sulfatoxymelatonin-d4 | 6-Sulfatoxymelatonin-d4 is the deuterated-labeled 6-Sulfatoxymelatonin. 6-Sulfatoxymelatonin is a metabolite of Melatonin (HY-B0075) and serves as a detection marker for Melatonin. 6-Sulfatoxymelatonin shows a decreasing trend with increasing age, and its urinary excretion is closely correlated with plasma Melatonin levels, which can reflect changes in the secretion phase of melatonin. 6-Sulfatoxymelatonin is associated with reduced risks of diabetic retinopathy and coronary heart disease, and can act as a biomarker for microvascular and macrovascular complications of type 2 diabetes mellitus. 6-Sulfatoxymelatonin can be used in studies related to type 2 diabetes mellitus and coronary heart disease. | |||||||||||||||||||||
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6-Sulfatoxymelatonin-d4 ammonium hydrate | 6-Sulfatoxymelatonin-d4 ammonium hydrate is the deuterated-labeled 6-Sulfatoxymelatonin ammonium hydrate. 6-Sulfatoxymelatonin ammonium hydrate is a metabolite of Melatonin (HY-B0075) and serves as a detection marker for Melatonin. 6-Sulfatoxymelatonin ammonium hydrate shows a decreasing trend with increasing age, and its urinary excretion is closely correlated with plasma Melatonin levels, which can reflect changes in the secretion phase of melatonin. 6-Sulfatoxymelatonin ammonium hydrate is associated with reduced risks of diabetic retinopathy and coronary heart disease, and can act as a biomarker for microvascular and macrovascular complications of type 2 diabetes mellitus. 6-Sulfatoxymelatonin ammonium hydrate can be used in studies related to type 2 diabetes mellitus and coronary heart disease. | |||||||||||||||||||||
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References
- [1]. Zheng Y, et al. Melatonin alleviates vascular endothelial cell damage by regulating an autophagy-apoptosis axis in Kawasaki disease. Cell proliferation. 2022 Jun;55(6):e13251.
- [2]. Tanaka K, et al. Associations between urinary 6-sulfatoxymelatonin excretion and diabetic vascular complications or arteriosclerosis in patients with type 2 diabetes. Journal of diabetes investigation. 2021 Apr;12(4):601-609.
- [3]. van Faassen M, et al. Mass spectrometric quantification of urinary 6-sulfatoxymelatonin: age-dependent excretion and biological variation. Clinical chemistry and laboratory medicine. 2020 Jul 16;59(1):187-195.
- [4]. Bojkowski CJ, et al. Factors influencing urinary 6-sulphatoxymelatonin, a major melatonin metabolite, in normal human subjects. Clinical endocrinology. 1990 Oct;33(4):435-44.
