1310349-35-9
1310349-35-9
Chemical Structure
BACE1-IN-1 hydrochloride
- CAS No.: 1310349-35-9
- Formula:C18H15ClF3N5O2
- Molecular Weight:425.79
InChIKey: CNXVOHMMAKBONG-UNTBIKODSA-N
SMILES: C[C@]1(C(F)(COC(N)=N1)F)C2=CC(NC(C3=CC=C(C=N3)C#N)=O)=CC=C2F.Cl
Biological Activity: BACE1-IN-1 hydrochloride is an orally active, blood-brain barrier penetrant dual-target inhibitor of BACE1/2, with IC50 values of 23 nM and 24 nM against human BACE1 and BACE2, respectively. BACE1-IN-1 hydrochloride reduces cerebral Aβ40 levels in mice. BACE1-IN-1 hydrochloride can be used in studies related to Alzheimer's disease and type 2 diabetes[1][2].
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BACE1-IN-1 hydrochloride | BACE1-IN-1 hydrochloride is an orally active, blood-brain barrier penetrant dual-target inhibitor of BACE1/2, with IC50 values of 23 nM and 24 nM against human BACE1 and BACE2, respectively. BACE1-IN-1 hydrochloride reduces cerebral Aβ40 levels in mice. BACE1-IN-1 hydrochloride can be used in studies related to Alzheimer's disease and type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Banner D, et al. Preparation of 2-amino-5, 5-difluoro-5, 6-dihydro-4H-oxazine derivatives as BACE1 and/or BACE2 inhibitors[J]. International Patent WO2011069934.(c) Shishido, Y, 2011: 7193-7205.
- [2]. Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95. [Content Brief]
