1310796-72-5
1310796-72-5
Chemical Structure
PF-4178903
Synonym(s): INCB10820
- CAS No.: 1310796-72-5
- Formula:C25H37F3N4O3
- Molecular Weight:498.58
IUPAC Name: ((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl)amino)cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone
InChIKey: DQWSENNLMPJNRJ-WHLIWEHUSA-N
SMILES: O=C(N1CCN(C2=CC(C(F)(F)F)=CC=N2)CC1)[C@@]3(C[C@@H](CC3)N[C@@H]4[C@@H](COCC4)OC)C(C)C
Biological Activity: PF-4178903 (INCB10820) is an orally active, potent dual CCR2 and CCR5 antagonist with IC50 values of 3 nM and 5.3 nM, respectively. PF-4178903 is promising for research of chronic inflammatory and autoimmune diseases[1].
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PF-4178903 | PF-4178903 (INCB10820) is an orally active, potent dual CCR2 and CCR5 antagonist with IC50 values of 3 nM and 5.3 nM, respectively. PF-4178903 is promising for research of chronic inflammatory and autoimmune diseases. | |||||||||||||||||||||
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