1313027-43-8
1313027-43-8
Chemical Structure
MM 54
- CAS No.: 1313027-43-8
- Formula:C70H121N29O15S4
- Molecular Weight:1737.16
InChIKey: VNWKTOKETHGBQD-UHFFFAOYSA-N
SMILES: O=C1N2[C@@](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H]1CCCNC(N)=N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@H]3NC([C@@H](NC([C@@H](NC([C@@]4([H])N(CCC4)C([C@@H](NC([C@H](CSSC3)N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)=O)CC5=CN=CN5)=O)C(O)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)([H])CCC2
Biological Activity: MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MM 54 | 99.62% | MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation. | ||||||||||||||||||||
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References
- [1]. N J Maximilian Macaluso, et al. Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem. 2011 Jun 6;6(6):1017-23. [Content Brief]
- [2]. Elizabeth Harford-Wright, et al. Pharmacological targeting of apelin impairs glioblastoma growth. Brain. 2017 Nov 1;140(11):2939-2954. [Content Brief]
