131359-77-8
Chemical Structure
SPAI-1
- CAS No.: 131359-77-8
- Formula:C245H386N72O65S8
- Molecular Weight:5628.57
SMILES: O=C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC1=CNC=N1)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(NCC(N[C@H]2CC3=CC=CC=C3)=O)=O)=O)NC4=O)C(N5[C@@H](CCC5)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@H]4NC7=O)C(N8[C@@H](CCC8)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N9[C@@H](CCC9)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@@H](CCCCN)C(N[C@H]%10CC(O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CC%13=CC=C(C=C%13)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC%14=CC=C(C=C%14)O)C(N%15[C@@H](CCC%15)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)NC%10=O)C(N%16[C@@H](CCC%16)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@H]7CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Biological Activity: SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na+, K+-ATPase and H+, K+-ATPase in vitro, stimulates Mg2+-ATPase[1][2].
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SPAI-1 | SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na+, K+-ATPase and H+, K+-ATPase in vitro, stimulates Mg2+-ATPase. | |||||||||||||||||||||
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References
- [1]. Araki K, et al. Novel peptide inhibitor (SPAI) of Na+, K+-ATPase from porcine intestine. Biochem Biophys Res Commun. 1989 Oct 16;164(1):496-502. [Content Brief]
- [2]. Ishizuka N, et al. Na+,K(+)-ATPase inhibition by an endogenous peptide, SPAI-1, isolated from porcine duodenum. Biochim Biophys Acta. 1991 Nov 4;1069(2):259-66. [Content Brief]
