1314096-69-9
1314096-69-9
Chemical Structure
BMK-Y101
- CAS No.: 1314096-69-9
- Formula:C12H14BrN5O5
- Molecular Weight:388.17
InChIKey: QVFBAVHEHBUGMY-YJMZUNRSSA-N
SMILES: O[C@H]1[C@H](O)[C@H](O[C@H]1CO)N2C=NC(N)=C3C2=NC(Br)=C3C(N)=O
Biological Activity: BMK-Y101 is a potent CDK kinase inhibitor. BMK-Y101 induces tumor cell apoptosis by inhibiting CDK kinases. BMK-Y101 can be used for research on hepatocellular carcinoma[1][2][3].
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BMK-Y101 | BMK-Y101 is a potent CDK kinase inhibitor. BMK-Y101 induces tumor cell apoptosis by inhibiting CDK kinases. BMK-Y101 can be used for research on hepatocellular carcinoma. | |||||||||||||||||||||
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References
- [1]. KIM Y J, et al. Selectivity between N-1 and N-7 nucleosides: regioselective synthesis of BMK-Y101, a potent cdk7 and 9 inhibitor. Tetrahedron Letters, 2013, 54(41): 5484-5488.
- [2]. GANBOLD E O, et al. Raman spectroscopy and density functional theory study of energetically closely separated C2′‐endo and C3′‐endo pentose forms in purine nucleoside analogue drug‐gold conjugates. Journal of Raman Spectroscopy, 2018, 49(3): 424-430.
- [3]. PERLÍKOVÁ P, et al. Pyrrolo[2,3-d]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides [J]. MedChemComm, 2017, 8(12): 2213-2226.
