1314378-11-4
Chemical Structure
Bis-PEG4-NHS ester
- CAS No.: 1314378-11-4
- Formula:C20H28N2O12
- Molecular Weight:488.44
IUPAC Name: bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13-tetraoxahexadecanedioate
InChIKey: BQLKLYYHZOLCLV-UHFFFAOYSA-N
SMILES: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
Biological Activity: Bis-PEG4-NHS ester is a crosslinking reagent and amine-reactive modulator[1][2].Bis-PEG4-NHS ester reacts with primary amine groups on liposome surfaces via amide bond formation to covalently attach dibenzylcyclooctyne groups, with a hydrophilic PEG4 spacer reducing steric hindrance for subsequent click chemistry[1].Bis-PEG4-NHS ester enables site-specific antibody coupling to liposome surfaces via copper-free strain-promoted alkyne-azide cycloaddition click chemistry without disrupting liposome structure in minimal organic solvent volumes[1].Bis-PEG4-NHS ester undergoes hydrolysis during annealing to form -COOH groups that interact with PbI and FAI to enhance perovskite structural integrity, passivate defects, and modulate nucleation kinetics to regulate crystal growth[2].Bis-PEG4-NHS ester enhances device efficiency and long-term stability when used as an antisolvent additive for p-i-n perovskite solar cells[2].
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Bis-PEG4-NHS ester | 97.0% | Bis-PEG4-NHS ester is a crosslinking reagent and amine-reactive modulator.Bis-PEG4-NHS ester reacts with primary amine groups on liposome surfaces via amide bond formation to covalently attach dibenzylcyclooctyne groups, with a hydrophilic PEG4 spacer reducing steric hindrance for subsequent click chemistry.Bis-PEG4-NHS ester enables site-specific antibody coupling to liposome surfaces via copper-free strain-promoted alkyne-azide cycloaddition click chemistry without disrupting liposome structure in minimal organic solvent volumes.Bis-PEG4-NHS ester undergoes hydrolysis during annealing to form -COOH groups that interact with PbI and FAI to enhance perovskite structural integrity, passivate defects, and modulate nucleation kinetics to regulate crystal growth.Bis-PEG4-NHS ester enhances device efficiency and long-term stability when used as an antisolvent additive for p-i-n perovskite solar cells. | ||||||||||||||||||||
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References
- [1]. Gai M, et al. A bio-orthogonal functionalization strategy for site-specific coupling of antibodies on vesicle surfaces after self-assembly[J]. Polymer Chemis去try, 2020, 11(2): 527-540.
- [2]. Liu M, et al. Efficient and Stable p-i-n Perovskite Solar Cells Enabled by In Situ Functional Group Conversion. J Am Chem Soc. 2024;146(46):32105-32116. [Content Brief]
