1314594-23-4
1314594-23-4
Chemical Structure
PKR-IN-C51
- CAS No.: 1314594-23-4
- Formula:C23H21N5
- Molecular Weight:367.45
IUPAC Name: N-(2-(1H-indol-3-yl)ethyl)-4-(2-methyl-1H-indol-3-yl)pyrimidin-2-amine
InChIKey: IDAWNFCAFDXMER-UHFFFAOYSA-N
SMILES: CC(NC1=C2C=CC=C1)=C2C3=NC(NCCC4=CNC5=C4C=CC=C5)=NC=C3
Biological Activity: PKR-IN-C51 is an ATP-competitive protein kinase R (PKR) inhibitor with a human IC50 of 9 μM and a human Ki of 3.4 μM. PKR-IN-C51 blocks the activation of PKR, inhibits intracellular PKR activation in primary mouse macrophages, and shows no obvious cytotoxicity. PKR-IN-C51 can be used in studies related to the regulation of PKR-mediated signaling pathways[1].
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PKR-IN-C51 | 99.79% | PKR-IN-C51 is an ATP-competitive protein kinase R (PKR) inhibitor with a human IC50 of 9 μM and a human Ki of 3.4 μM. PKR-IN-C51 blocks the activation of PKR, inhibits intracellular PKR activation in primary mouse macrophages, and shows no obvious cytotoxicity. PKR-IN-C51 can be used in studies related to the regulation of PKR-mediated signaling pathways. | ||||||||||||||||||||
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