131875-08-6
131875-08-6
Chemical Structure
Lexacalcitol
Synonym(s): KH1060
- CAS No.: 131875-08-6
- Formula:C29H48O4
- Molecular Weight:460.69
IUPAC Name: (1R,3S,Z)-5-(2-((1S,3aS,7aS,E)-1-((R)-1-((4-ethyl-4-hydroxyhexyl)oxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
InChIKey: KLZOTDOJMRMLDX-YBBVPDDNSA-N
SMILES: C[C@]1(CCC/2)[C@](CC[C@@H]1[C@@H](C)OCCCC(CC)(CC)O)([H])C2=C\C=C(C[C@@H](O)C[C@@H]3O)/C3=C
Biological Activity: Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases[1][2].
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Lexacalcitol | Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases. | |||||||||||||||||||||
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(1S)-Calcitriol (Standard) | ≥98% | (1S)-Calcitriol (Standard) is the analytical standard of (1S)-Calcitriol (HY-10002A). This product is intended for research and analytical applications. (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion. | ||||||||||||||||||||
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(1R,5Z)-Calcitriol | (1R,5Z)-Calcitriol ((1R,5Z)-1,25-Dihydroxyvitamin D3) is a Calcitriol (HY-10002) isomer. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist. | |||||||||||||||||||||
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Calcitriol (Standard) | 99.94% | Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist. | ||||||||||||||||||||
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CB1151 | CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM. | |||||||||||||||||||||
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CB 966 | CB 966 a Vitamin D3 (HY-15398) analogue, is an immunosuppressant. CB 966 delays rejection of allogeneic skin grafts in mice. CB 966 moderately increases serum calcium levels. CB 966 can be used for the research of allogeneic skin graft rejection. | |||||||||||||||||||||
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Impurity B of Calcitriol | 98.04% | Impurity B of Calcitriol is a diastereomer of 1α,25-dihydroxyvitamin D3 that interferes with accurate Calcitriol quantification. | ||||||||||||||||||||
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Calcitriolc | 1α,25-Dihydroxyvitamin D3-(23,24,25,26,27-13C5) solution is the 13C labeled 1α,25-Dihydroxyvitamin D3. | |||||||||||||||||||||
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Maxacalcitol | 99.08% | Maxacalcitol (22-Oxacalcitriol), a vitamin D3 (HY-15398) analog, is an orally active VDR agonist. Maxacalcitol has a limited calcemic effect. Maxacalcitol has the potential for psoriasis and hyperparathyroidism research. | ||||||||||||||||||||
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Calcitriol Impurities A | 99.78% | Calcitriol Impurities A is an impurity of Calcitriol (HY-10002). Calcitriol is the active metabolite of vitamin D3 and can activate the vitamin D receptor. | ||||||||||||||||||||
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Calcitriol Impurities D | 95.18% | Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). | ||||||||||||||||||||
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References
- [1]. L Binderup, et al. 20-epi-vitamin D3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol. 1991 Sep 27;42(8):1569-75. [Content Brief]
- [2]. C Gysemans, et al. A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice. Transplant Proc. 2001 May;33(3):2365. [Content Brief]
