13192-04-6
Chemical Structure
Dimethyl 2-oxoglutarate
Synonym(s): Dimethyl α-ketoglutarate
- CAS No.: 13192-04-6
- Formula:C7H10O5
- Molecular Weight:174.15
IUPAC Name: dimethyl 2-oxopentanedioate
InChIKey: TXIXSLPEABAEHP-UHFFFAOYSA-N
SMILES: O=C(OC)C(CCC(OC)=O)=O
Biological Activity: Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate) is a cell-permeable derivative of 2-oxoglutarate and tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate inhibits Autophagy. Dimethyl 2-oxoglutarate prevents mitochondrial damage and reduces ROS production. Dimethyl 2-oxoglutarate alleviates Carbon tetrachloride (HY-Y0298)-induced liver fibrosis. Dimethyl-2-oxoglutaric acid can be used in the research of diseases such as Alzheimer's disease, diabetes, and cardiomyopathy[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dimethyl 2-oxoglutarate | 97.50% | Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate) is a cell-permeable derivative of 2-oxoglutarate and tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate inhibits Autophagy. Dimethyl 2-oxoglutarate prevents mitochondrial damage and reduces ROS production. Dimethyl 2-oxoglutarate alleviates Carbon tetrachloride (HY-Y0298)-induced liver fibrosis. Dimethyl-2-oxoglutaric acid can be used in the research of diseases such as Alzheimer's disease, diabetes, and cardiomyopathy. | ||||||||||||||||||||
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Dimethyl 2-oxoglutarate (Standard) | 97.77% | Dimethyl 2-oxoglutarate (Standard) (Dimethyl α-ketoglutarate (Standard)) is the analytical standard of Dimethyl 2-oxoglutarate (HY-44134). This product is intended for research and analytical applications. Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate) is a cell-permeable derivative of 2-oxoglutarate and tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate inhibits Autophagy. Dimethyl 2-oxoglutarate prevents mitochondrial damage and reduces ROS production. Dimethyl 2-oxoglutarate alleviates Carbon tetrachloride (HY-Y0298)-induced liver fibrosis. Dimethyl-2-oxoglutaric acid can be used in the research of diseases such as Alzheimer's disease, diabetes, and cardiomyopathy. | ||||||||||||||||||||
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References
- [1]. Faulkner A, et al. Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus. Diabetologia. 2020 Oct;63(10):2205-2217. [Content Brief]
- [2]. Mariño G, et al. Dimethyl α-ketoglutarate inhibits maladaptive autophagy in pressure overload-induced cardiomyopathy. Autophagy. 2014 May;10(5):930-2. [Content Brief]
- [3]. Zhao J, et al. Dimethyl α-ketoglutarate reduces CCl4-induced liver fibrosis through inhibition of autophagy in hepatic stellate cells. Biochem Biophys Res Commun. 2016 Dec 2;481(1-2):90-96. [Content Brief]
- [4]. Chauhan A, et al. Dimethyl-2-oxoglutarate but not antioxidants prevents glucose hypometabolism induced neural cell death: implications in the pathogenesis and therapy of Alzheimer's disease. Biochem Biophys Rep. 2025 Jul 12;43:102150. [Content Brief]
