132173-06-9
132173-06-9
Chemical Structure
SR-31747 free base
- CAS No.: 132173-06-9
- Formula:C23H34ClN
- Molecular Weight:359.98
IUPAC Name: (Z)-N-(3-(3-chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine
InChIKey: MYKJVLTXPNIGOV-KTKRTIGZSA-N
SMILES: CCN(C/C=C\C1=CC=C(C2CCCCC2)C(Cl)=C1)C3CCCCC3
Biological Activity: SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2].
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SR-31747 free base | SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase. | |||||||||||||||||||||
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References
- [1]. Derocq JM, et al. In vivo inhibition of endotoxin-induced pro-inflammatory cytokines production by the sigma ligand SR 31747. J Pharmacol Exp Ther. 1995 Jan;272(1):224-30. [Content Brief]
- [2]. Silve S, et al. The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun;16(6):2719-27. [Content Brief]
